6MJW

human cGAS catalytic domain bound with the inhibitor G150

Summary for 6MJW

Entry DOI	10.2210/pdb6mjw/pdb
Descriptor	Cyclic GMP-AMP synthase, ZINC ION, 1-[9-(6-aminopyridin-3-yl)-6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]-2-hydroxyethan-1-one, ... (4 entities in total)
Functional Keywords	human cgas, dna sensor, inhibitor, immune system, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	43942.71
Authors	Lama, L.,Adura, C.,Xie, W.,Tomita, D.,Kamei, T.,Kuryavyi, V.,Gogakos, T.,Steinberg, J.I.,Miller, M.,Ramos-Espiritu, L.,Asano, Y.,Hashizume, S.,Aida, J.,Imaeda, T.,Okamoto, R.,Jennings, A.J.,Michinom, M.,Kuroita, T.,Stamford, A.,Gao, P.,Meinke, P.,Glickman, J.F.,Patel, D.J.,Tuschl, T. (deposition date: 2018-09-23, release date: 2019-05-29, Last modification date: 2024-03-13)
Primary citation	Lama, L.,Adura, C.,Xie, W.,Tomita, D.,Kamei, T.,Kuryavyi, V.,Gogakos, T.,Steinberg, J.I.,Miller, M.,Ramos-Espiritu, L.,Asano, Y.,Hashizume, S.,Aida, J.,Imaeda, T.,Okamoto, R.,Jennings, A.J.,Michino, M.,Kuroita, T.,Stamford, A.,Gao, P.,Meinke, P.,Glickman, J.F.,Patel, D.J.,Tuschl, T. Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression. Nat Commun, 10:2261-2261, 2019 Cited by PubMed: 31113940 DOI: 10.1038/s41467-019-08620-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.405 Å)

Structure validation