6MHM

Crystal structure of human acid ceramidase in covalent complex with carmofur

Summary for 6MHM

• Entry DOI: 10.2210/pdb6mhm/pdb
• Related PRD ID: PRD_900017
• Descriptor: Acid ceramidase subunit alpha, Acid ceramidase subunit beta, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: acid ceramidase, acid ceramidase inhibitors, benzoxazolone carboxamides, carmofur, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 92452.01

Authors

Dementiev, A.,Joachimiak, A.,Doan, N. (deposition date: 2018-09-18, release date: 2019-01-23, Last modification date: 2023-10-11)

• Primary citation: Dementiev, A.,Joachimiak, A.,Nguyen, H.,Gorelik, A.,Illes, K.,Shabani, S.,Gelsomino, M.,Ahn, E.E.,Nagar, B.,Doan, N.; Molecular Mechanism of Inhibition of Acid Ceramidase by Carmofur.; J. Med. Chem., 62:987-992, 2019; PubMed: 30525581; DOI: 10.1021/acs.jmedchem.8b01723

Experimental method

X-RAY DIFFRACTION (2.743 Å)