6M8C

Crystal structure of the core catalytic domain of human inositol phosphate multikinase in complex with isorhamnetin

Summary for 6M8C

Entry DOI	10.2210/pdb6m8c/pdb
Descriptor	Inositol polyphosphate multikinase,Inositol polyphosphate multikinase, isorhamnetin (3 entities in total)
Functional Keywords	kinase, inositol, inositol polyphosphate, transferase, isorhamnetin, flavonoid, inhibitor, natural product
Biological source	Homo sapiens (Human) More
Total number of polymer chains	1
Total formula weight	30144.17
Authors	Wang, H.,Shears, S.B. (deposition date: 2018-08-21, release date: 2019-01-23, Last modification date: 2023-10-11)
Primary citation	Gu, C.,Stashko, M.A.,Puhl-Rubio, A.C.,Chakraborty, M.,Chakraborty, A.,Frye, S.V.,Pearce, K.H.,Wang, X.,Shears, S.B.,Wang, H. Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure-Activity Analysis. J. Med. Chem., 62:1443-1454, 2019 Cited by PubMed: 30624931 DOI: 10.1021/acs.jmedchem.8b01593 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation