6M1S
The DNA Gyrase B ATP binding domain of PSEUDOMONAS AERUGINOSA in complex with compound 12o
Summary for 6M1S
Entry DOI | 10.2210/pdb6m1s/pdb |
Descriptor | DNA gyrase subunit B, 3-[5-[8-(ethylamino)-6-fluoranyl-4-[3-(trifluoromethyl)pyrazol-1-yl]-9H-pyrido[2,3-b]indol-3-yl]pyrimidin-2-yl]oxy-2,2-dimethyl-propanoic acid, SULFATE ION, ... (5 entities in total) |
Functional Keywords | dna gyrase, topoisomerase, atpase domain, isomerase |
Biological source | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) |
Total number of polymer chains | 2 |
Total formula weight | 49197.00 |
Authors | |
Primary citation | Hu, Y.,Shi, H.,Zhou, M.,Ren, Q.,Zhu, W.,Zhang, W.,Zhang, Z.,Zhou, C.,Liu, Y.,Ding, X.,Shen, H.C.,Yan, S.F.,Dey, F.,Wu, W.,Zhai, G.,Zhou, Z.,Xu, Z.,Ji, Y.,Lv, H.,Jiang, T.,Wang, W.,Xu, Y.,Vercruysse, M.,Yao, X.,Mao, Y.,Yu, X.,Bradley, K.,Tan, X. Discovery of Pyrido[2,3-b]indole Derivatives with Gram-Negative Activity Targeting Both DNA Gyrase and Topoisomerase IV. J.Med.Chem., 63:9623-9649, 2020 Cited by PubMed: 32787097DOI: 10.1021/acs.jmedchem.0c00768 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.254 Å) |
Structure validation
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