6KYA
Crystal structure of human TLR8 in complex TH1027
Summary for 6KYA
Entry DOI | 10.2210/pdb6kya/pdb |
Descriptor | Toll-like receptor 8, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | immune system |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 192191.03 |
Authors | Tanji, H.,Sakaniwa, K.,Ohto, U.,Shimizu, T. (deposition date: 2019-09-17, release date: 2020-05-27, Last modification date: 2023-11-22) |
Primary citation | Jiang, S.,Tanji, H.,Yin, K.,Zhang, S.,Sakaniwa, K.,Huang, J.,Yang, Y.,Li, J.,Ohto, U.,Shimizu, T.,Yin, H. Rationally Designed Small-Molecule Inhibitors Targeting an Unconventional Pocket on the TLR8 Protein-Protein Interface. J.Med.Chem., 63:4117-4132, 2020 Cited by PubMed: 32233366DOI: 10.1021/acs.jmedchem.9b02128 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.89 Å) |
Structure validation
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