6KW7
Crystal structure of indoleamine 2,3-dioxygenagse 1 (IDO1) in complex with compound 12
Summary for 6KW7
Entry DOI | 10.2210/pdb6kw7/pdb |
Descriptor | Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, 3-(4-bromophenyl)imidazo[2,1-b][1,3]thiazole, ... (4 entities in total) |
Functional Keywords | tryptophan catabolism, heme, iron, metal binding, kynurenine, immunity, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 92559.71 |
Authors | Peng, Y.H.,Wu, S.Y. (deposition date: 2019-09-06, release date: 2020-03-25, Last modification date: 2023-11-22) |
Primary citation | Peng, Y.H.,Liao, F.Y.,Tseng, C.T.,Kuppusamy, R.,Li, A.S.,Chen, C.H.,Fan, Y.S.,Wang, S.Y.,Wu, M.H.,Hsueh, C.C.,Chang, J.Y.,Lee, L.C.,Shih, C.,Shia, K.S.,Yeh, T.K.,Hung, M.S.,Kuo, C.C.,Song, J.S.,Wu, S.Y.,Ueng, S.H. Unique Sulfur-Aromatic Interactions Contribute to the Binding of Potent Imidazothiazole Indoleamine 2,3-Dioxygenase Inhibitors. J.Med.Chem., 63:1642-1659, 2020 Cited by PubMed: 31961685DOI: 10.1021/acs.jmedchem.9b01549 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.02 Å) |
Structure validation
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