6KPR
Quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with B12155 inhibitor
Summary for 6KPR
| Entry DOI | 10.2210/pdb6kpr/pdb |
| Descriptor | Bifunctional dihydrofolate reductase-thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total) |
| Functional Keywords | dihydrofolate reductase, plasmodium falciparum, antimalarial, antifolate, antibiotic, oxidoreductase, transferase |
| Biological source | Plasmodium falciparum (malaria parasite P. falciparum) |
| Total number of polymer chains | 2 |
| Total formula weight | 147021.50 |
| Authors | Vanichtanankul, J.,Vitsupakorn, D. (deposition date: 2019-08-15, release date: 2019-12-04, Last modification date: 2023-11-22) |
| Primary citation | Saepua, S.,Sadorn, K.,Vanichtanankul, J.,Anukunwithaya, T.,Rattanajak, R.,Vitsupakorn, D.,Kamchonwongpaisan, S.,Yuthavong, Y.,Thongpanchang, C. 6-Hydrophobic aromatic substituent pyrimethamine analogues as potential antimalarials for pyrimethamine-resistant Plasmodium falciparum. Bioorg.Med.Chem., 27:115158-115158, 2019 Cited by PubMed: 31685330DOI: 10.1016/j.bmc.2019.115158 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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