6KKV
Structural basis for domain rotation during adenylation of active site K123 and fragment library screening against NAD+ -dependent DNA ligase from Mycobacterium tuberculosis
Summary for 6KKV
Entry DOI | 10.2210/pdb6kkv/pdb |
Descriptor | DNA ligase A, N-[(4-methylphenyl)methyl]-1H-pyrrole-2-carboxamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | ligase |
Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Total number of polymer chains | 1 |
Total formula weight | 37310.55 |
Authors | Ramachandran, R.,Shukla, A.,Afsar, M. (deposition date: 2019-07-27, release date: 2020-07-29, Last modification date: 2023-11-22) |
Primary citation | Shukla, A.,Afsar, M.,Kumar, N.,Kumar, S.,Ramachandran, R. Structure based identification of first-in-class fragment inhibitors that target the NMN pocket of M. tuberculosis NAD + -dependent DNA ligase A. J.Struct.Biol., 213:107655-107655, 2021 Cited by PubMed: 33197566DOI: 10.1016/j.jsb.2020.107655 PDB entries with the same primary citation |
Experimental method |
Structure validation
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