6KEI
Crystal structure of BRD4 bromodomain 1 (BD1) in complex with 16-methoxy-11-methyl-6-[(pyridin-2-yl)methoxy]-2-oxa-11-azatetracyclo[8.6.1.03,8.013,17]heptadeca-1(16),3,5,7,9,13(17),14-heptaen-12-one
Summary for 6KEI
Entry DOI | 10.2210/pdb6kei/pdb |
Descriptor | Bromodomain-containing protein 4, 16-methoxy-11-methyl-6-[(pyridin-2-yl)methoxy]-2-oxa-11-azatetracyclo[8.6.1.03,8.013,17]heptadeca-1(16),3,5,7,9,13(17),14-heptaen-12-one, FORMIC ACID, ... (4 entities in total) |
Functional Keywords | brd4, bromodomain 1, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 15503.68 |
Authors | Lee, B.I.,Park, T.H. (deposition date: 2019-07-04, release date: 2020-07-08, Last modification date: 2023-11-22) |
Primary citation | Yoo, M.,Park, T.H.,Yoo, M.,Kim, Y.,Lee, J.Y.,Lee, K.M.,Ryu, S.E.,Lee, B.I.,Jung, K.Y.,Park, C.H. Synthesis and Structure-Activity Relationships of Aristoyagonine Derivatives as Brd4 Bromodomain Inhibitors with X-ray Co-Crystal Research. Molecules, 26:-, 2021 Cited by PubMed: 33802888DOI: 10.3390/molecules26061686 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.451 Å) |
Structure validation
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