6JF0
Covalent labeling of hPPARg-LBD by turn-on fluorescent probe mediated by conjugate addition and cyclization
Summary for 6JF0
| Entry DOI | 10.2210/pdb6jf0/pdb |
| Descriptor | Peroxisome proliferator-activated receptor gamma, methyl (2~{S})-3-[4-[3-(4-methoxy-2-oxidanyl-phenyl)prop-2-ynoyloxy]phenyl]-2-[[2-(phenylcarbonyl)phenyl]amino]propanoate, 7-methoxychromen-2-one, ... (4 entities in total) |
| Functional Keywords | receptor, covalent labeling, cysteine, turn-on fluorescent probe, tcc probe, nuclear protein |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 63624.78 |
| Authors | Kojima, H.,Yamamoto, K.,Itoh, T. (deposition date: 2019-02-07, release date: 2020-02-12, Last modification date: 2023-11-22) |
| Primary citation | Kojima, H.,Fujita, Y.,Takeuchi, R.,Ikebe, Y.,Ohashi, N.,Yamamoto, K.,Itoh, T. Cyclization Reaction-Based Turn-on Probe for Covalent Labeling of Target Proteins. Cell Chem Biol, 27:334-, 2020 Cited by PubMed: 31991094DOI: 10.1016/j.chembiol.2020.01.006 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.4 Å) |
Structure validation
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