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6JEY

Covalent bond formation between ynone moiety of synthetic fatty acid and hPPARg-LBD

Summary for 6JEY
Entry DOI10.2210/pdb6jey/pdb
DescriptorPeroxisome proliferator-activated receptor gamma, (9Z,12Z,15Z,18Z,21Z)-5-oxidanylidenetetracosa-9,12,15,18,21-pentaen-6-ynoic acid (3 entities in total)
Functional Keywordsreceptor, covalent ligand, ynone, oxo-fatty acid, nuclear protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight64004.57
Authors
Kojima, H.,Yamamoto, K.,Itoh, T. (deposition date: 2019-02-07, release date: 2020-02-12, Last modification date: 2023-11-22)
Primary citationKojima, H.,Fujita, Y.,Takeuchi, R.,Ikebe, Y.,Ohashi, N.,Yamamoto, K.,Itoh, T.
Cyclization Reaction-Based Turn-on Probe for Covalent Labeling of Target Proteins.
Cell Chem Biol, 27:334-, 2020
Cited by
PubMed: 31991094
DOI: 10.1016/j.chembiol.2020.01.006
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

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