6I6R

New Irreversible a-l-Iduronidase Inhibitors and Activity-Based Probes

Summary for 6I6R

Entry DOI	10.2210/pdb6i6r/pdb
Descriptor	Alpha-L-iduronidase, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, (1~{R},2~{R},3~{R},4~{S},6~{S})-6-azanyl-2,3,4-tris(oxidanyl)cyclohexane-1-carboxylic acid, ... (8 entities in total)
Functional Keywords	iduronidase inhibitors gh39, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	143044.20
Authors	Gloster, T.M.,McMahon, S.A.,Oehler, V. (deposition date: 2018-11-15, release date: 2018-12-05, Last modification date: 2024-01-24)
Primary citation	Artola, M.,Kuo, C.L.,McMahon, S.A.,Oehler, V.,Hansen, T.,van der Lienden, M.,He, X.,van den Elst, H.,Florea, B.I.,Kermode, A.R.,van der Marel, G.A.,Gloster, T.M.,Codee, J.D.C.,Overkleeft, H.S.,Aerts, J.M.F.G. New Irreversible alpha-l-Iduronidase Inhibitors and Activity-Based Probes. Chemistry, 24:19081-19088, 2018 Cited by PubMed: 30307091 DOI: 10.1002/chem.201804662 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.02 Å)

Structure validation