6I6P
SEPIAPTERIN REDUCTASE IN COMPLEX WITH COMPOUND 3
Summary for 6I6P
| Entry DOI | 10.2210/pdb6i6p/pdb |
| Descriptor | Sepiapterin reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-azaspiro[3.4]octan-6-yl-[2,4-bis(chloranyl)-6-oxidanyl-phenyl]methanone, ... (5 entities in total) |
| Functional Keywords | sepiapterin-reductase, oxidoreductase, proteros biostructures gmbh |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 62170.30 |
| Authors | Alen, J.,Schade, M.,Wagener, M.,Blaesse, M. (deposition date: 2018-11-15, release date: 2019-07-10, Last modification date: 2019-07-24) |
| Primary citation | Alen, J.,Schade, M.,Wagener, M.,Christian, F.,Nordhoff, S.,Merla, B.,Dunkern, T.R.,Bahrenberg, G.,Ratcliffe, P. Fragment-Based Discovery of Novel Potent Sepiapterin Reductase Inhibitors. J.Med.Chem., 62:6391-6397, 2019 Cited by PubMed: 31244106DOI: 10.1021/acs.jmedchem.9b00218 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.62 Å) |
Structure validation
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