6I6C

SEPIAPTERIN REDUCTASE IN COMPLEX WITH COMPOUND 2

Summary for 6I6C

Entry DOI	10.2210/pdb6i6c/pdb
Descriptor	Sepiapterin reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (1~{R},2~{S},4~{S})-~{N}-(3-chloranyl-4-cyano-phenyl)sulfonylbicyclo[2.2.1]heptane-2-carboxamide, ... (5 entities in total)
Functional Keywords	sepiapterin-reductase, oxidoreductase, proteros biostructures gmbh
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	62495.83
Authors	Alen, J.,Schade, M.,Wagener, M.,Blaesse, M. (deposition date: 2018-11-15, release date: 2019-07-10, Last modification date: 2019-07-24)
Primary citation	Alen, J.,Schade, M.,Wagener, M.,Christian, F.,Nordhoff, S.,Merla, B.,Dunkern, T.R.,Bahrenberg, G.,Ratcliffe, P. Fragment-Based Discovery of Novel Potent Sepiapterin Reductase Inhibitors. J.Med.Chem., 62:6391-6397, 2019 Cited by PubMed: 31244106 DOI: 10.1021/acs.jmedchem.9b00218 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.72 Å)

Structure validation