6I5H
Crystal structure of CLK1 in complex with furanopyrimidin VN412
Summary for 6I5H
Entry DOI | 10.2210/pdb6i5h/pdb |
Descriptor | Dual specificity protein kinase CLK1, 1,2-ETHANEDIOL, GLYCEROL, ... (5 entities in total) |
Functional Keywords | protein tyrosine kinase, dual specificity, splicing, human, inhibitor, structural genomics, structural genomics consortium, sgc, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 40351.35 |
Authors | Schroeder, M.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Paruch, K.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2018-11-13, release date: 2019-01-16, Last modification date: 2024-01-24) |
Primary citation | Nemec, V.,Hylsova, M.,Maier, L.,Flegel, J.,Sievers, S.,Ziegler, S.,Schroder, M.,Berger, B.T.,Chaikuad, A.,Valcikova, B.,Uldrijan, S.,Drapela, S.,Soucek, K.,Waldmann, H.,Knapp, S.,Paruch, K. Furo[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway. Angew. Chem. Int. Ed. Engl., 58:1062-1066, 2019 Cited by PubMed: 30569600DOI: 10.1002/anie.201810312 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.49 Å) |
Structure validation
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