6I11
CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 3
Summary for 6I11
Entry DOI | 10.2210/pdb6i11/pdb |
Descriptor | Fascin, ACETATE ION, ~{N}-(1-methylpyrazol-4-yl)-1-oxidanylidene-2-(phenylmethyl)isoquinoline-4-carboxamide, ... (4 entities in total) |
Functional Keywords | actin bundling, small molecule inhibition, structural protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 55019.32 |
Authors | Schuettelkopf, A.W. (deposition date: 2018-10-27, release date: 2019-02-27, Last modification date: 2024-01-24) |
Primary citation | Francis, S.,Croft, D.,Schuttelkopf, A.W.,Parry, C.,Pugliese, A.,Cameron, K.,Claydon, S.,Drysdale, M.,Gardner, C.,Gohlke, A.,Goodwin, G.,Gray, C.H.,Konczal, J.,McDonald, L.,Mezna, M.,Pannifer, A.,Paul, N.R.,Machesky, L.,McKinnon, H.,Bower, J. Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents. Bioorg.Med.Chem.Lett., 29:1023-1029, 2019 Cited by PubMed: 30773430DOI: 10.1016/j.bmcl.2019.01.035 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.67 Å) |
Structure validation
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