6HT1
Crystal structure of MLLT1 (ENL) YEATS domain in complexed with SGC-iMLLT (compound 92)
Summary for 6HT1
Entry DOI | 10.2210/pdb6ht1/pdb |
Related | 6HT0 |
Descriptor | Protein ENL, SULFATE ION, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | transcription, yeats domain, enl, mllt1, chemical probe, inhibitor, structural genomics, structural genomics consortium, sgc |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 19327.15 |
Authors | Heidenreich, D.,Chaikuad, A.,Moustakim, M.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Fedorov, O.,Brennan, P.E.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2018-10-02, release date: 2018-10-17, Last modification date: 2024-01-24) |
Primary citation | Moustakim, M.,Christott, T.,Monteiro, O.P.,Bennett, J.,Giroud, C.,Ward, J.,Rogers, C.M.,Smith, P.,Panagakou, I.,Diaz-Saez, L.,Felce, S.L.,Gamble, V.,Gileadi, C.,Halidi, N.,Heidenreich, D.,Chaikuad, A.,Knapp, S.,Huber, K.V.M.,Farnie, G.,Heer, J.,Manevski, N.,Poda, G.,Al-Awar, R.,Dixon, D.J.,Brennan, P.E.,Fedorov, O. Discovery of an MLLT1/3 YEATS Domain Chemical Probe. Angew. Chem. Int. Ed. Engl., 57:16302-16307, 2018 Cited by PubMed: 30288907DOI: 10.1002/anie.201810617 PDB entries with the same primary citation |
Experimental method |
Structure validation
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