6HOW
Trypanosoma brucei PTR1 in complex with the triazine inhibitor 2a (F219).
Summary for 6HOW
Entry DOI | 10.2210/pdb6how/pdb |
Related | 6HNC 6HNR |
Descriptor | Pteridine reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2~{R})-1-(3,4-dichlorophenyl)-2-(4-nitrophenyl)-2~{H}-1,3,5-triazine-4,6-diamine, ... (5 entities in total) |
Functional Keywords | trypanosoma brucei, pteridine reductase, ptr1, tbptr1, triazine inhibitors, oxidoreductase |
Biological source | Trypanosoma brucei brucei More |
Total number of polymer chains | 4 |
Total formula weight | 126806.38 |
Authors | Landi, G.,Pozzi, C.,Mangani, S. (deposition date: 2018-09-18, release date: 2019-05-08, Last modification date: 2024-01-24) |
Primary citation | Landi, G.,Linciano, P.,Borsari, C.,Bertolacini, C.P.,Moraes, C.B.,Cordeiro-da-Silva, A.,Gul, S.,Witt, G.,Kuzikov, M.,Costi, M.P.,Pozzi, C.,Mangani, S. Structural Insights into the Development of Cycloguanil Derivatives asTrypanosoma bruceiPteridine-Reductase-1 Inhibitors. Acs Infect Dis., 5:1105-1114, 2019 Cited by PubMed: 31012301DOI: 10.1021/acsinfecdis.8b00358 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.92 Å) |
Structure validation
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