6HID
The ATAD2 bromodomain in complex with compound 16
Summary for 6HID
Entry DOI | 10.2210/pdb6hid/pdb |
Descriptor | ATPase family AAA domain-containing protein 2, SULFATE ION, ~{N}-[4-ethanoyl-5-(4-morpholin-4-ylcarbonylphenyl)-1,3-thiazol-2-yl]piperazine-2-carboxamide, ... (4 entities in total) |
Functional Keywords | bromodomain, atad2, inhibitor, complex, cytosolic protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 16436.61 |
Authors | Sledz, P.,Caflisch, A. (deposition date: 2018-08-29, release date: 2019-02-20, Last modification date: 2024-01-17) |
Primary citation | Dolbois, A.,Batiste, L.,Wiedmer, L.,Dong, J.,Brutsch, M.,Huang, D.,Deerain, N.M.,Spiliotopoulos, D.,Cheng-Sanchez, I.,Laul, E.,Nevado, C.,Sledz, P.,Caflisch, A. Hitting a Moving Target: Simulation and Crystallography Study of ATAD2 Bromodomain Blockers. Acs Med.Chem.Lett., 11:1573-1580, 2020 Cited by PubMed: 32832026DOI: 10.1021/acsmedchemlett.0c00080 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.768 Å) |
Structure validation
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