6HDQ
N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH : 8-(((1R,2R,3R,5S)-2-(2-(4,4-difluorocyclohexyl)ethyl)-8-azabicyclo[3.2.1]octan-3-yl)amino)-3-methyl-5-(5-methylpyridin-3-yl)-1,7-naphthyridin-2(1H)-one
Summary for 6HDQ
Entry DOI | 10.2210/pdb6hdq/pdb |
Descriptor | Bromodomain-containing protein 4, 1,2-ETHANEDIOL, 8-(((1R,2R,3R,5S)-2-(2-(4,4-difluorocyclohexyl)ethyl)-8-azabicyclo[3.2.1]octan-3-yl)amino)-3-methyl-5-(5-methylpyridin-3-yl)-1,7-naphthyridin-2(1H)-one, ... (4 entities in total) |
Functional Keywords | inhibitor, histone, epigenetic reader, bromodomain, brd4, bromodomain containing protein 4, antagonist, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 15683.09 |
Authors | Chung, C. (deposition date: 2018-08-18, release date: 2018-09-26, Last modification date: 2024-05-15) |
Primary citation | Bamborough, P.,Chung, C.W.,Furze, R.C.,Grandi, P.,Michon, A.M.,Watson, R.J.,Mitchell, D.J.,Barnett, H.,Prinjha, R.K.,Rau, C.,Sheppard, R.J.,Werner, T.,Demont, E.H. Aiming to Miss a Moving Target: Bromo and Extra Terminal Domain (BET) Selectivity in Constrained ATAD2 Inhibitors. J. Med. Chem., 61:8321-8336, 2018 Cited by PubMed: 30226378DOI: 10.1021/acs.jmedchem.8b00862 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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