6GXE

Carbonic Anhydrase CAIX mimic in complex with inhibitor JS14

Summary for 6GXE

• Entry DOI: 10.2210/pdb6gxe/pdb
• Related: 6GXB
• Descriptor: Carbonic anhydrase 2, ZINC ION, 3-[2-[2-[2-[2-(aminomethyloxy)ethoxy]ethoxy]ethoxy]ethoxy]-~{N}-[4-[4-[(4-sulfamoylphenyl)carbamoylamino]phenoxy]butyl]propanamide, ... (5 entities in total)
• Functional Keywords: carbonic anhydrase, caii mutant to caix mimic, ca inhibitor, lyase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 30299.53

Authors

Brynda, J.,Rezacova, P.,Pospisilova, K. (deposition date: 2018-06-27, release date: 2019-05-08, Last modification date: 2024-05-15)

• Primary citation: Pospisilova, K.,Knedlik, T.,Sacha, P.,Kostka, L.,Schimer, J.,Brynda, J.,Kral, V.,Cigler, P.,Navratil, V.,Etrych, T.,Subr, V.,Kugler, M.,Fabry, M.,Rezacova, P.,Konvalinka, J.; Inhibitor-Polymer Conjugates as a Versatile Tool for Detection and Visualization of Cancer-Associated Carbonic Anhydrase Isoforms; Acs Omega, 2019; DOI: 10.1021/acsomega.9b00596

Experimental method

X-RAY DIFFRACTION (1.3 Å)