6GK0
HUMAN DIHYDROOROTATE DEHYDROGENASE IN COMPLEX WITH CLASS III HISTONE DEACETYLASE INHIBITOR
Summary for 6GK0
| Entry DOI | 10.2210/pdb6gk0/pdb |
| Descriptor | Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, ... (10 entities in total) |
| Functional Keywords | dehydrogenase dhodh tumor-killing drug development, antitumor protein |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 41975.04 |
| Authors | Hakansson, M.,Ladds, M.J.G.W.,Walse, B.,Lain, S. (deposition date: 2018-05-17, release date: 2019-11-27, Last modification date: 2024-05-15) |
| Primary citation | Ladds, M.J.G.W.,Popova, G.,Pastor-Fernandez, A.,Kannan, S.,van Leeuwen, I.M.M.,Hakansson, M.,Walse, B.,Tholander, F.,Bhatia, R.,Verma, C.S.,Lane, D.P.,Lain, S. Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology. J.Biol.Chem., 295:17935-17949, 2020 Cited by PubMed: 32900849DOI: 10.1074/jbc.RA119.012056 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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