6FMJ
pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-Acetamidopropanethioyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl) benzyl)pyrrolidine-2-carboxamide (ligand 3)
Summary for 6FMJ
Entry DOI | 10.2210/pdb6fmj/pdb |
Descriptor | Elongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ... (5 entities in total) |
Functional Keywords | protein complex, ubiquitin ligase, hypoxia inducible factor, ligase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 12 |
Total formula weight | 164462.44 |
Authors | Soares, P.,Lucas, X.,Ciulli, A. (deposition date: 2018-01-31, release date: 2018-04-11, Last modification date: 2018-06-20) |
Primary citation | Soares, P.,Lucas, X.,Ciulli, A. Thioamide substitution to probe the hydroxyproline recognition of VHL ligands. Bioorg. Med. Chem., 26:2992-2995, 2018 Cited by PubMed: 29650462DOI: 10.1016/j.bmc.2018.03.034 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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