6F83
Crystal Structure of Human Galectin-1 in Complex With Thienyl-1,2, 3-triazolyl Thiodigalactoside Inhibitor
Summary for 6F83
Entry DOI | 10.2210/pdb6f83/pdb |
Descriptor | Galectin-1, 3-deoxy-3-[4-(thiophen-3-yl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranosyl 3-deoxy-1-thio-3-[4-(thiophen-3-yl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranoside (3 entities in total) |
Functional Keywords | carbohydrate-recognition, beta sandwich, carbohydrate binding protein, sugar binding protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 31209.55 |
Authors | Collins, P.M.,Blanchard, H. (deposition date: 2017-12-12, release date: 2019-01-30, Last modification date: 2024-01-17) |
Primary citation | Peterson, A.,Collins, P.M.,Kahl-Knutsson, B.,Zetterberg, F.R.,Blanchard, H.,Leffler, H.,Nilsson, U.J. Aromatic heterocycle galectin-1 interactions for selective single-digit nM affinity ligands To be published, |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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