6F6N
CRYSTAL STRUCTURE OF EBOLAVIRUS GLYCOPROTEIN IN COMPLEX WITH SERTRALINE
Summary for 6F6N
Entry DOI | 10.2210/pdb6f6n/pdb |
Related | 6F5U 6F6I |
Descriptor | Envelope glycoprotein,Envelope glycoprotein,GP1, Envelope glycoprotein, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total) |
Functional Keywords | ebola virus, filoviridae, envelope glycoprotein, protein inhibitor complex, ibuprofen, benztropine, bepridil, paroxetine, sertraline, toremifene, viral protein |
Biological source | Zaire ebolavirus (strain Mayinga-76) (ZEBOV) More |
Total number of polymer chains | 2 |
Total formula weight | 57865.53 |
Authors | Ren, J.,Zhao, Y.,Fry, E.E.,Stuart, D.I. (deposition date: 2017-12-05, release date: 2018-01-03, Last modification date: 2024-01-17) |
Primary citation | Ren, J.,Zhao, Y.,Fry, E.E.,Stuart, D.I. Target Identification and Mode of Action of Four Chemically Divergent Drugs against Ebolavirus Infection. J. Med. Chem., 61:724-733, 2018 Cited by PubMed: 29272110DOI: 10.1021/acs.jmedchem.7b01249 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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