6EWK
T. californica AChE in complex with a 3-hydroxy-2-pyridine aldoxime.
Summary for 6EWK
Entry DOI | 10.2210/pdb6ewk/pdb |
Descriptor | Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-[(~{E})-hydroxyiminomethyl]-6-(5-morpholin-4-ylpentyl)pyridin-3-ol, ... (5 entities in total) |
Functional Keywords | acetylcholinesterase, reactivator, aldehyde oxime, organophosphate poisoning, hydrolase |
Biological source | Tetronarce californica (Pacific electric ray) |
Total number of polymer chains | 1 |
Total formula weight | 61865.80 |
Authors | de la Mora, E.,Weik, M.,Braiki, A.,Mougeot, R.,Jean, L.,Renard, P.I. (deposition date: 2017-11-04, release date: 2018-11-14, Last modification date: 2020-07-29) |
Primary citation | Zorbaz, T.,Braiki, A.,Marakovic, N.,Renou, J.,de la Mora, E.,Macek Hrvat, N.,Katalinic, M.,Silman, I.,Sussman, J.L.,Mercey, G.,Gomez, C.,Mougeot, R.,Perez, B.,Baati, R.,Nachon, F.,Weik, M.,Jean, L.,Kovarik, Z.,Renard, P.Y. Potent 3-Hydroxy-2-Pyridine Aldoxime Reactivators of Organophosphate-Inhibited Cholinesterases with Predicted Blood-Brain Barrier Penetration. Chemistry, 24:9675-9691, 2018 Cited by PubMed: 29672968DOI: 10.1002/chem.201801394 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.22 Å) |
Structure validation
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