6EQ3
MTH1 in complex with fragment 9
Summary for 6EQ3
Entry DOI | 10.2210/pdb6eq3/pdb |
Descriptor | 7,8-dihydro-8-oxoguanine triphosphatase, [2-(1~{H}-pyrrolo[2,3-b]pyridin-4-yl)-1,3-thiazol-4-yl]methanol, SULFATE ION, ... (4 entities in total) |
Functional Keywords | inhibitor, complex, hydrolase, dna repair, fragment |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 21432.26 |
Authors | Wiedmer, L.,Sledz, P.,Caflisch, A. (deposition date: 2017-10-12, release date: 2018-10-31, Last modification date: 2024-05-08) |
Primary citation | Wiedmer, L.,Scharer, C.,Spiliotopoulos, D.,Hurzeler, M.,Sledz, P.,Caflisch, A. Ligand retargeting by binding site analogy. Eur.J.Med.Chem., 175:107-113, 2019 Cited by PubMed: 31077996DOI: 10.1016/j.ejmech.2019.04.037 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.798 Å) |
Structure validation
Download full validation report