6E0I
Crystal structure of Glucokinase in complex with compound 72
Summary for 6E0I
Entry DOI | 10.2210/pdb6e0i/pdb |
Descriptor | Glucokinase, alpha-D-glucopyranose, DIMETHYL SULFOXIDE, ... (5 entities in total) |
Functional Keywords | glucokinase, glucokinase activator, structure-aided design, structure-based design, type ii diabetes, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 52303.42 |
Authors | Hinklin, R.J.,Baer, B.R.,Boyd, S.A.,Chicarelli, M.D.,Condroski, K.R.,DeWolf, W.E.,Fischer, J.,Frank, M.,Hingorani, G.P.,Lee, P.A.,Neitzel, N.A.,Pratt, S.A.,Singh, A.,Sullivan, F.X.,Turner, T.,Voegtli, W.C.,Wallace, E.M.,Williams, L.,Aicher, T.D. (deposition date: 2018-07-06, release date: 2019-07-10, Last modification date: 2024-03-13) |
Primary citation | Hinklin, R.J.,Baer, B.R.,Boyd, S.A.,Chicarelli, M.D.,Condroski, K.R.,DeWolf Jr., W.E.,Fischer, J.,Frank, M.,Hingorani, G.P.,Lee, P.A.,Neitzel, N.A.,Pratt, S.A.,Singh, A.,Sullivan, F.X.,Turner, T.,Voegtli, W.C.,Wallace, E.M.,Williams, L.,Aicher, T.D. Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator. Bioorg.Med.Chem., 28:115232-115232, 2020 Cited by PubMed: 31818630DOI: 10.1016/j.bmc.2019.115232 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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