6E0E

Crystal structure of Glucokinase in complex with compound 6

Summary for 6E0E

Entry DOI	10.2210/pdb6e0e/pdb
Descriptor	Glucokinase, alpha-D-glucopyranose, 2-({2-[(4-methyl-1,3-thiazol-2-yl)amino]pyridin-3-yl}oxy)benzonitrile, ... (4 entities in total)
Functional Keywords	glucokinase, glucokinase activator, structure-aided design, structure-based design, type ii diabetes, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	50752.55
Authors	Hinklin, R.J.,Baer, B.R.,Boyd, S.A.,Chicarelli, M.D.,Condroski, K.R.,DeWolf, W.E.,Fischer, J.,Frank, M.,Hingorani, G.P.,Lee, P.A.,Neitzel, N.A.,Pratt, S.A.,Singh, A.,Sullivan, F.X.,Turner, T.,Voegtli, W.C.,Wallace, E.M.,Williams, L.,Aicher, T.D. (deposition date: 2018-07-06, release date: 2019-07-10, Last modification date: 2024-03-13)
Primary citation	Hinklin, R.J.,Baer, B.R.,Boyd, S.A.,Chicarelli, M.D.,Condroski, K.R.,DeWolf Jr., W.E.,Fischer, J.,Frank, M.,Hingorani, G.P.,Lee, P.A.,Neitzel, N.A.,Pratt, S.A.,Singh, A.,Sullivan, F.X.,Turner, T.,Voegtli, W.C.,Wallace, E.M.,Williams, L.,Aicher, T.D. Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator. Bioorg.Med.Chem., 28:115232-115232, 2020 Cited by PubMed: 31818630 DOI: 10.1016/j.bmc.2019.115232 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation