6DZW
Cryo-EM structure of the ts2-inactive human serotonin transporter in complex with paroxetine and 15B8 Fab and 8B6 ScFv
Summary for 6DZW
Entry DOI | 10.2210/pdb6dzw/pdb |
EMDB information | 8941 |
Descriptor | Sodium-dependent serotonin transporter, 8B6 antibody single chain, 15B8 antibody heavy chain, ... (7 entities in total) |
Functional Keywords | paroxetine, antidepressant, human serotonin transporter, fab, transport protein-immune system complex, transport protein/immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 112431.40 |
Authors | Coleman, J.A.,Yang, D.,Gouaux, E. (deposition date: 2018-07-05, release date: 2019-04-24, Last modification date: 2020-07-29) |
Primary citation | Coleman, J.A.,Yang, D.,Zhao, Z.,Wen, P.C.,Yoshioka, C.,Tajkhorshid, E.,Gouaux, E. Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport. Nature, 569:141-145, 2019 Cited by PubMed: 31019304DOI: 10.1038/s41586-019-1135-1 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4.3 Å) |
Structure validation
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