6DWD
SAMHD1 Bound to Clofarabine-TP in the Catalytic Pocket and Allosteric Pocket
Summary for 6DWD
Entry DOI | 10.2210/pdb6dwd/pdb |
Descriptor | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, 9-{2-deoxy-2-fluoro-5-O-[(R)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-arabinofuranosyl}-2-me thyl-9H-purin-6-amine, GUANOSINE-5'-TRIPHOSPHATE, ... (10 entities in total) |
Functional Keywords | complex, deoxynucleoside triphosphate triphosphohydrolase, dntpase, nucleotide analogue, clofarabine-tp, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 261862.43 |
Authors | Knecht, K.M.,Buzovetsky, O.,Schneider, C.,Thomas, D.,Srikanth, V.,Kaderali, L.,Tofoleanu, F.,Reiss, K.,Ferreiros, N.,Geisslinger, G.,Batista, V.S.,Ji, X.,Cinatl, J.,Keppler, O.T.,Xiong, Y. (deposition date: 2018-06-26, release date: 2018-10-10, Last modification date: 2024-03-13) |
Primary citation | Knecht, K.M.,Buzovetsky, O.,Schneider, C.,Thomas, D.,Srikanth, V.,Kaderali, L.,Tofoleanu, F.,Reiss, K.,Ferreiros, N.,Geisslinger, G.,Batista, V.S.,Ji, X.,Cinatl Jr., J.,Keppler, O.T.,Xiong, Y. The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1. Proc. Natl. Acad. Sci. U.S.A., 115:E10022-E10031, 2018 Cited by PubMed: 30305425DOI: 10.1073/pnas.1805593115 PDB entries with the same primary citation |
Experimental method |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)