6DFJ

Crystal structure of anti-Zika antibody Z021 bound to DENV-1 envelope protein DIII

Summary for 6DFJ

• Entry DOI: 10.2210/pdb6dfj/pdb
• Descriptor: anti-Zika antibody Z021, Heavy Chain, anti-Zika antibody Z021, Light Chain, Dengue 1 Envelope DIII domain, ... (4 entities in total)
• Functional Keywords: antibody, fab, zika, dengue, recurrent, neutralizing, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 59393.34

Authors

Keeffe, J.R.,Bjorkman, P.J. (deposition date: 2018-05-14, release date: 2018-10-24, Last modification date: 2018-11-14)

• Primary citation: Keeffe, J.R.,Van Rompay, K.K.A.,Olsen, P.C.,Wang, Q.,Gazumyan, A.,Azzopardi, S.A.,Schaefer-Babajew, D.,Lee, Y.E.,Stuart, J.B.,Singapuri, A.,Watanabe, J.,Usachenko, J.,Ardeshir, A.,Saeed, M.,Agudelo, M.,Eisenreich, T.,Bournazos, S.,Oliveira, T.Y.,Rice, C.M.,Coffey, L.L.,MacDonald, M.R.,Bjorkman, P.J.,Nussenzweig, M.C.,Robbiani, D.F.; A Combination of Two Human Monoclonal Antibodies Prevents Zika Virus Escape Mutations in Non-human Primates.; Cell Rep, 25:1385-1394.e7, 2018; PubMed: 30403995; DOI: 10.1016/j.celrep.2018.10.031

Experimental method

X-RAY DIFFRACTION (2.07 Å)