6D5L
Ras:SOS:Ras in complex with a small molecule activator
Summary for 6D5L
Entry DOI | 10.2210/pdb6d5l/pdb |
Descriptor | GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (10 entities in total) |
Functional Keywords | ras, sos, inhibitor, oncoprotein, protein-protein complex, mapk, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 95787.26 |
Authors | Phan, J.,Hodges, T.,Fesik, S.W. (deposition date: 2018-04-19, release date: 2018-09-19, Last modification date: 2023-11-15) |
Primary citation | Hodges, T.R.,Abbott, J.R.,Little, A.J.,Sarkar, D.,Salovich, J.M.,Howes, J.E.,Akan, D.T.,Sai, J.,Arnold, A.L.,Browning, C.,Burns, M.C.,Sobolik, T.,Sun, Q.,Beesetty, Y.,Coker, J.A.,Scharn, D.,Stadtmueller, H.,Rossanese, O.W.,Phan, J.,Waterson, A.G.,McConnell, D.B.,Fesik, S.W. Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS. J. Med. Chem., 61:8875-8894, 2018 Cited by PubMed: 30205005DOI: 10.1021/acs.jmedchem.8b01108 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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