6D0D
X-ray crystal structure of wild type HIV-1 protease in complex with GRL-087-13
Summary for 6D0D
Entry DOI | 10.2210/pdb6d0d/pdb |
Descriptor | Protease, (3aS,4S,7aR)-hexahydro-4H-furo[2,3-b]pyran-4-yl [(2S,3R)-1-(4-fluorophenyl)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}butan-2-yl]carbamate (3 entities in total) |
Functional Keywords | hiv-1 protease, protease inhibitor, darunavir, fluorophenyl, nonpeptidic, tmc-126, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22202.20 |
Authors | Yedidi, R.S.,Hayashi, H.,Ghosh, A.K.,Mitsuya, H. (deposition date: 2018-04-10, release date: 2019-05-01, Last modification date: 2023-10-04) |
Primary citation | Amano, M.,Salcedo-Gomez, P.M.,Yedidi, R.S.,Zhao, R.,Hayashi, H.,Hasegawa, K.,Nakamura, T.,Martyr, C.D.,Ghosh, A.K.,Mitsuya, H. Novel Central Nervous System (CNS)-Targeting Protease Inhibitors for Drug-Resistant HIV Infection and HIV-Associated CNS Complications. Antimicrob.Agents Chemother., 63:-, 2019 Cited by PubMed: 31061155DOI: 10.1128/AAC.00466-19 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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