6CQY
Crystal Structure of Recombinant Human Acetylcholinesterase in Complex with EMPA and HI-6
Summary for 6CQY
Entry DOI | 10.2210/pdb6cqy/pdb |
Related | 6CQT 6CQU 6CQV 6CQW 6CQX 6CQZ |
Descriptor | Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | hydrolase cholinesterase, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 121302.47 |
Authors | Bester, S.M.,Guelta, M.A.,Pegan, S.D.,Height, J.J. (deposition date: 2018-03-16, release date: 2018-12-05, Last modification date: 2023-10-04) |
Primary citation | Bester, S.M.,Guelta, M.A.,Cheung, J.,Winemiller, M.D.,Bae, S.Y.,Myslinski, J.,Pegan, S.D.,Height, J.J. Structural Insights of Stereospecific Inhibition of Human Acetylcholinesterase by VX and Subsequent Reactivation by HI-6. Chem. Res. Toxicol., 31:1405-1417, 2018 Cited by PubMed: 30462502DOI: 10.1021/acs.chemrestox.8b00294 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.449 Å) |
Structure validation
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