6CN8

High-resolution structure of ClpC1-NTD binding to Rufomycin-I

Summary for 6CN8

Entry DOI	10.2210/pdb6cn8/pdb
Related PRD ID	PRD_002306
Descriptor	ATP-dependent Clp protease ATP-binding subunit ClpC1, Rufomycin I, PHOSPHATE ION, ... (6 entities in total)
Functional Keywords	mycobacterium tuberculosis, rufomycin i, macrocyclic peptide, clpc1-ntd, chaperone, atp-dependent protease, chaperone-antibiotic complex, atpase aaa+, natural product, chaperone/antibiotic
Biological source	Mycobacterium tuberculosis More
Total number of polymer chains	2
Total formula weight	18922.15
Authors	Abad-Zapatero, C.,Wolf, N.W. (deposition date: 2018-03-07, release date: 2019-06-05, Last modification date: 2023-11-15)
Primary citation	Wolf, N.M.,Lee, H.,Choules, M.P.,Pauli, G.F.,Phansalkar, R.,Anderson, J.R.,Gao, W.,Ren, J.,Santarsiero, B.D.,Lee, H.,Cheng, J.,Jin, Y.Y.,Ho, N.A.,Duc, N.M.,Suh, J.W.,Abad-Zapatero, C.,Cho, S. High-Resolution Structure of ClpC1-Rufomycin and Ligand Binding Studies Provide a Framework to Design and Optimize Anti-Tuberculosis Leads. Acs Infect Dis., 5:829-840, 2019 Cited by PubMed: 30990022 DOI: 10.1021/acsinfecdis.8b00276 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation