6CMM
Crystal Structure of the Human vaccinia-related kinase bound to a N,N-dipropynyl-dihydropteridine inhibitor
Summary for 6CMM
Entry DOI | 10.2210/pdb6cmm/pdb |
Descriptor | Serine/threonine-protein kinase VRK1, ACETATE ION, (7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-5,8-di(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5H)-one, ... (6 entities in total) |
Functional Keywords | transferase, protein kinase domain, structural genomics, structural genomics consortium, sgc, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 166474.05 |
Authors | dos Reis, C.V.,de Souza, G.P.,Counago, R.M.,Azevedo, A.,Guimaraes, C.,Mascarello, A.,Gama, F.,Ferreira, M.,Massirer, K.B.,Arruda, P.,Edwards, A.M.,Elkins, J.M.,Structural Genomics Consortium (SGC) (deposition date: 2018-03-05, release date: 2018-03-21, Last modification date: 2023-10-04) |
Primary citation | dos Reis, C.V.,de Souza, G.P.,Counago, R.M.,Azevedo, H.,Guimaraes, C.,Mascarello, A.,Gama, F.,Ferreira, M.,Massirer, K.B.,Arruda, P.,Edwards, A.M.,Elkins, J.M.,Structural Genomics Consortium (SGC) Crystal Structure of the Human vaccinia-related kinase bound to a N,N-dipropynyl-dihydropteridine inhibitor To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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