6CJY

Crystal Structure of Mnk2-D228G in complex with Inhibitor

Summary for 6CJY

• Entry DOI: 10.2210/pdb6cjy/pdb
• Related: 6CJ5
• Descriptor: MAP kinase-interacting serine/threonine-protein kinase 2, ZINC ION, 5-[(7H-purin-6-yl)amino]-1H-isoindol-1-one, ... (4 entities in total)
• Functional Keywords: mnk2 inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Isoform 2: Nucleus, PML body. Isoform 1: Cytoplasm: Q9HBH9
• Total number of polymer chains: 1
• Total formula weight: 35934.11

Authors

Han, Q. (deposition date: 2018-02-27, release date: 2018-05-09)

• Primary citation: Reich, S.H.,Sprengeler, P.A.,Chiang, G.G.,Appleman, J.R.,Chen, J.,Clarine, J.,Eam, B.,Ernst, J.T.,Han, Q.,Goel, V.K.,Han, E.Z.R.,Huang, V.,Hung, I.N.J.,Jemison, A.,Jessen, K.A.,Molter, J.,Murphy, D.,Neal, M.,Parker, G.S.,Shaghafi, M.,Sperry, S.,Staunton, J.,Stumpf, C.R.,Thompson, P.A.,Tran, C.,Webber, S.E.,Wegerski, C.J.,Zheng, H.,Webster, K.R.; Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition.; J. Med. Chem., 61:3516-3540, 2018; PubMed: 29526098; DOI: 10.1021/acs.jmedchem.7b01795

Experimental method

X-RAY DIFFRACTION (3.05 Å)