6CIS
Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor JWG047
Summary for 6CIS
Entry DOI | 10.2210/pdb6cis/pdb |
Descriptor | Bromodomain-containing protein 4, 11-cyclopentyl-5-methyl-2-({4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]-2-[(propan-2-yl)oxy]phenyl}amino)-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | kinase, inhibitor, brd4, transcription, transcription-inhibitor complex, transcription/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 15742.19 |
Authors | Xu, X.,Blacklow, S.C. (deposition date: 2018-02-25, release date: 2018-08-29, Last modification date: 2023-10-04) |
Primary citation | Wang, J.,Erazo, T.,Ferguson, F.M.,Buckley, D.L.,Gomez, N.,Munoz-Guardiola, P.,Dieguez-Martinez, N.,Deng, X.,Hao, M.,Massefski, W.,Fedorov, O.,Offei-Addo, N.K.,Park, P.M.,Dai, L.,DiBona, A.,Becht, K.,Kim, N.D.,McKeown, M.R.,Roberts, J.M.,Zhang, J.,Sim, T.,Alessi, D.R.,Bradner, J.E.,Lizcano, J.M.,Blacklow, S.C.,Qi, J.,Xu, X.,Gray, N.S. Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains. ACS Chem. Biol., 13:2438-2448, 2018 Cited by PubMed: 30102854DOI: 10.1021/acschembio.7b00638 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.51 Å) |
Structure validation
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