6CEC
Crystal structure of fragment 3-(3-Methoxy-2-quinoxalinyl)propanoic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain
Summary for 6CEC
Entry DOI | 10.2210/pdb6cec/pdb |
Descriptor | Histone deacetylase 6, ZINC ION, UNKNOWN ATOM OR ION, ... (5 entities in total) |
Functional Keywords | histone deacetylase, hdac, hdac6, ubiquitin, structural genomics consortium, sgc, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: Q9UBN7 |
Total number of polymer chains | 1 |
Total formula weight | 12361.07 |
Authors | Harding, R.J.,Halabelian, L.,Ferreira de Freitas, R.,Franzoni, I.,Ravichandran, M.,Lautens, M.,Santhakumar, V.,Schapira, M.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.M.,Structural Genomics Consortium (SGC) (deposition date: 2018-02-11, release date: 2018-02-28, Last modification date: 2023-10-04) |
Primary citation | Ferreira de Freitas, R.,Harding, R.J.,Franzoni, I.,Ravichandran, M.,Mann, M.K.,Ouyang, H.,Lautens, M.,Santhakumar, V.,Arrowsmith, C.H.,Schapira, M. Identification and Structure-Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors. J. Med. Chem., 61:4517-4527, 2018 Cited by PubMed: 29741882DOI: 10.1021/acs.jmedchem.8b00258 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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