6C57
Crystal structure of mutant human geranylgeranyl pyrophosphate synthase (Y246D) in complex with bisphosphonate inhibitor FV0109
Summary for 6C57
Entry DOI | 10.2210/pdb6c57/pdb |
Descriptor | Geranylgeranyl pyrophosphate synthase, {[(2-{3-[(4-fluorobenzene-1-carbonyl)amino]phenyl}thieno[2,3-d]pyrimidin-4-yl)amino]methylene}bis(phosphonic acid) (3 entities in total) |
Functional Keywords | isoprenoid pathway, isopentenyl transferase, transferase inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 75391.36 |
Authors | Park, J.,Bin, X.,Vincent, F.,Tsantrizos, Y.S.,Berghuis, A.M. (deposition date: 2018-01-15, release date: 2018-09-05, Last modification date: 2023-10-04) |
Primary citation | Lacbay, C.M.,Waller, D.D.,Park, J.,Gomez Palou, M.,Vincent, F.,Huang, X.F.,Ta, V.,Berghuis, A.M.,Sebag, M.,Tsantrizos, Y.S. Unraveling the Prenylation-Cancer Paradox in Multiple Myeloma with Novel Geranylgeranyl Pyrophosphate Synthase (GGPPS) Inhibitors. J. Med. Chem., 61:6904-6917, 2018 Cited by PubMed: 30016091DOI: 10.1021/acs.jmedchem.8b00886 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.5 Å) |
Structure validation
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