6C56
Crystal structure of mutant human geranylgeranyl pyrophosphate synthase (Y246D) in its Apo form
Summary for 6C56
| Entry DOI | 10.2210/pdb6c56/pdb |
| Descriptor | Geranylgeranyl pyrophosphate synthase, {[(2-phenylthieno[2,3-d]pyrimidin-4-yl)amino]methylene}bis(phosphonic acid) (3 entities in total) |
| Functional Keywords | isoprenoid pathway, isopentenyl transferase, transferase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 75254.25 |
| Authors | Park, J.,Ta, V.,Tsantrizos, Y.S.,Berghuis, A.M. (deposition date: 2018-01-15, release date: 2018-09-05, Last modification date: 2023-10-04) |
| Primary citation | Lacbay, C.M.,Waller, D.D.,Park, J.,Gomez Palou, M.,Vincent, F.,Huang, X.F.,Ta, V.,Berghuis, A.M.,Sebag, M.,Tsantrizos, Y.S. Unraveling the Prenylation-Cancer Paradox in Multiple Myeloma with Novel Geranylgeranyl Pyrophosphate Synthase (GGPPS) Inhibitors. J. Med. Chem., 61:6904-6917, 2018 Cited by PubMed: 30016091DOI: 10.1021/acs.jmedchem.8b00886 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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