6C0M
The synthesis, biological evaluation and structural insights of unsaturated 3-N-substituted sialic acids as probes of human parainfluenza virus-3 haemagglutinin-neuraminidase
Summary for 6C0M
Entry DOI | 10.2210/pdb6c0m/pdb |
Descriptor | Hemagglutinin-neuraminidase, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total) |
Functional Keywords | hemagglutinin-neuraminidase, inhibitor, sialic acid, human parainfluenza virus type 3, sialidase, viral protein, viral protein-inhibitor complex, viral protein/inhibitor |
Biological source | Human respirovirus 3 |
Total number of polymer chains | 2 |
Total formula weight | 99974.84 |
Authors | Dirr, L.,Ve, T.,von Itzstein, M. (deposition date: 2018-01-01, release date: 2018-06-27, Last modification date: 2023-10-04) |
Primary citation | Pascolutti, M.,Dirr, L.,Guillon, P.,Van Den Bergh, A.,Ve, T.,Thomson, R.J.,von Itzstein, M. Structural Insights into Human Parainfluenza Virus 3 Hemagglutinin-Neuraminidase Using Unsaturated 3- N-Substituted Sialic Acids as Probes. ACS Chem. Biol., 13:1544-1550, 2018 Cited by PubMed: 29693380DOI: 10.1021/acschembio.8b00150 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.83 Å) |
Structure validation
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