6BOE
TBK1 in complex with amide-coupled tetrazole analog of amlexanox
Summary for 6BOE
Entry DOI | 10.2210/pdb6boe/pdb |
Related | 6BNY 6BOD |
Descriptor | Serine/threonine-protein kinase TBK1, 2-amino-5-oxo-7-(propan-2-yl)-N-(1H-tetrazol-5-yl)-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxamide (2 entities in total) |
Functional Keywords | tbk1, kinase, amlexanox, obesity, diabetes, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 76391.27 |
Authors | Beyett, T.S.,Tesmer, J.J.G. (deposition date: 2017-11-19, release date: 2018-09-26, Last modification date: 2023-10-04) |
Primary citation | Beyett, T.S.,Gan, X.,Reilly, S.M.,Chang, L.,Gomez, A.V.,Saltiel, A.R.,Showalter, H.D.,Tesmer, J.J.G. Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKepsilonand Reveal Mechanisms for Selective Inhibition. Mol. Pharmacol., 94:1210-1219, 2018 Cited by PubMed: 30082428DOI: 10.1124/mol.118.112185 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.598 Å) |
Structure validation
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