6BN7
Crystal structure of DDB1-CRBN-BRD4(BD1) complex bound to dBET23 PROTAC.
Summary for 6BN7
Entry DOI | 10.2210/pdb6bn7/pdb |
Descriptor | DNA damage-binding protein 1, Protein cereblon, Bromodomain-containing protein 4, ... (5 entities in total) |
Functional Keywords | protac, degrader, e3 ligase, crbn, ligase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 165480.97 |
Authors | Nowak, R.P.,DeAngelo, S.L.,Buckley, D.,Bradner, J.E.,Fischer, E.S. (deposition date: 2017-11-16, release date: 2018-05-30, Last modification date: 2023-10-04) |
Primary citation | Nowak, R.P.,DeAngelo, S.L.,Buckley, D.,He, Z.,Donovan, K.A.,An, J.,Safaee, N.,Jedrychowski, M.P.,Ponthier, C.M.,Ishoey, M.,Zhang, T.,Mancias, J.D.,Gray, N.S.,Bradner, J.E.,Fischer, E.S. Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat. Chem. Biol., 14:706-714, 2018 Cited by PubMed: 29892083DOI: 10.1038/s41589-018-0055-y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.501 Å) |
Structure validation
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