5ZZ8

Structure of the Herpes simplex virus type 2 C-capsid with capsid-vertex-specific component

これはPDB形式変換不可エントリーです。

5ZZ8 の概要

• エントリーDOI: 10.2210/pdb5zz8/pdb
• EMDBエントリー: 6976
• 分子名称: VP19C, VP23, Major capsid protein, ... (7 entities in total)
• 機能のキーワード: herpes simplex virus 2, capsid, capsid-vertex-specific component, structural protein
• 由来する生物種: Human herpesvirus 2 (HHV-2); 詳細
• タンパク質・核酸の鎖数: 51
• 化学式量合計: 4032164.48

構造登録者

Wang, J.L.,Yuan, S.,Zhu, D.J.,Tang, H.,Wang, N.,Chen, W.Y.,Gao, Q.,Li, Y.H.,Wang, J.Z.,Liu, H.R.,Zhang, X.Z.,Rao, Z.H.,Wang, X.X. (登録日: 2018-05-31, 公開日: 2018-10-10, 最終更新日: 2024-11-20)

主引用文献

Wang, J.,Yuan, S.,Zhu, D.,Tang, H.,Wang, N.,Chen, W.,Gao, Q.,Li, Y.,Wang, J.,Liu, H.,Zhang, X.,Rao, Z.,Wang, X.
Structure of the herpes simplex virus type 2 C-capsid with capsid-vertex-specific component.
Nat Commun, 9:3668-3668, 2018

PubMed Abstract: Herpes simplex viruses (HSVs) cause human oral and genital ulcer diseases. Patients with HSV-2 have a higher risk of acquiring a human immunodeficiency virus infection. HSV-2 is a member of the α-herpesvirinae subfamily that together with the β- and γ-herpesvirinae subfamilies forms the Herpesviridae family. Here, we report the cryo-electron microscopy structure of the HSV-2 C-capsid with capsid-vertex-specific component (CVSC) that was determined at 3.75 Å using a block-based reconstruction strategy. We present atomic models of multiple conformers for the capsid proteins (VP5, VP23, VP19C, and VP26) and CVSC. Comparison of the HSV-2 homologs yields information about structural similarities and differences between the three herpesviruses sub-families and we identify α-herpesvirus-specific structural features. The hetero-pentameric CVSC, consisting of a UL17 monomer, a UL25 dimer and a UL36 dimer, is bound tightly by a five-helix bundle that forms extensive networks of subunit contacts with surrounding capsid proteins, which reinforce capsid stability.

PubMed: 30201968
DOI: 10.1038/s41467-018-06078-4

実験手法

ELECTRON MICROSCOPY (3.75 Å)