5ZXA

Crystal structure of fibronectin-binding protein Apa mutant from Mycobacterium tuberculosis

5ZXA の概要

• エントリーDOI: 10.2210/pdb5zxa/pdb
• 分子名称: Alanine and proline-rich secreted protein Apa, MERCURY (II) ION, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: substrate binding, cyclolavandulyl diphosphate synthase, inhibitor, protein binding
• 由来する生物種: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33066.27

構造登録者

Gao, J.,Liu, W.D.,Chen, C.C.,Guo, R.T. (登録日: 2018-05-18, 公開日: 2019-05-29, 最終更新日: 2024-03-27)

主引用文献

Kuo, C.J.,Gao, J.,Huang, J.W.,Ko, T.P.,Zhai, C.,Ma, L.,Liu, W.,Dai, L.,Chang, Y.F.,Chen, T.H.,Hu, Y.,Yu, X.,Guo, R.T.,Chen, C.C.
Functional and structural investigations of fibronectin-binding protein Apa from Mycobacterium tuberculosis.
Biochim Biophys Acta Gen Subj, 1863:1351-1359, 2019

PubMed Abstract: Alanine and proline-rich protein (Apa) is a secreted antigen of Mycobacterium spp. which involves in stimulating immune responses and adhering to host cells by binding to fibronectin (Fn). Here, we report the crystal structure of Apa from Mycobacterium tuberculosis (Mtb) and its Fn-binding characteristics.

PubMed: 31175911
DOI: 10.1016/j.bbagen.2019.06.003

実験手法

X-RAY DIFFRACTION (1.77 Å)