5ZTO

Crystal structure of EGFR 696-1022 T790M/C797S in complex with D3003

Summary for 5ZTO

DescriptorEpidermal growth factor receptor, N-{trans-4-[3-(2-chlorophenyl)-7-{[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl]cyclohexyl}propanamide, CHLORIDE ION, ... (4 entities in total)
Functional Keywordsegfr, t790m/c797s, inhibitor, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total molecular weight38287.17
Authors
Zhu, S.J.,Yun, C.H. (deposition date: 2018-05-04, release date: 2019-06-12)
Primary citation
Zhu, S.J.,Yun, C.H.
Crystal structure of EGFR 696-1022 T790M/C797S in complex with D3003
To Be Published,
Experimental method
X-RAY DIFFRACTION (2.649 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.271120 7.0% 4.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution