5ZSB

Crystal structure of monkey TLR7 in complex with IMDQ and AAUUAA

Summary for 5ZSB

• Entry DOI: 10.2210/pdb5zsb/pdb
• Descriptor: Toll-like receptor 7, RNA (5'-R(*AP*UP*UP*AP*A)-3'), 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: innate immunity toll-like receptors, immune system
• Biological source: Macaca mulatta (Rhesus macaque); More
• Total number of polymer chains: 4
• Total formula weight: 198933.83

Authors

Zhang, Z.,Ohto, U.,Shimizu, T. (deposition date: 2018-04-28, release date: 2019-01-30, Last modification date: 2024-03-13)

• Primary citation: Zhang, Z.,Ohto, U.,Shibata, T.,Taoka, M.,Yamauchi, Y.,Sato, R.,Shukla, N.M.,David, S.A.,Isobe, T.,Miyake, K.,Shimizu, T.; Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands.; Cell Rep, 25:3371-3381.e5, 2018; PubMed: 30566863; DOI: 10.1016/j.celrep.2018.11.081

Experimental method

X-RAY DIFFRACTION (2.7 Å)