5ZRT

Crystal structure of human C1ORF123 protein

5ZRT の概要

• エントリーDOI: 10.2210/pdb5zrt/pdb
• 分子名称: UPF0587 protein C1orf123, GLYCEROL, CHLORIDE ION, ... (6 entities in total)
• 機能のキーワード: human hypothetical protein, unknown function
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 41312.01

構造登録者

Rahaman, S.N.A.,Yusop, J.M.,Mohamed-Hussein, Z.A.,Wan Mohd, A.,Ho, K.L.,Teh, A.H.,Waterman, J.,Ng, C.L. (登録日: 2018-04-25, 公開日: 2018-08-01, 最終更新日: 2023-11-22)

主引用文献

A Rahaman, S.N.,Mat Yusop, J.,Mohamed-Hussein, Z.A.,Aizat, W.M.,Ho, K.L.,Teh, A.H.,Waterman, J.,Tan, B.K.,Tan, H.L.,Li, A.Y.,Chen, E.S.,Ng, C.L.
Crystal structure and functional analysis of human C1ORF123.
Peerj, 6:e5377-e5377, 2018

PubMed Abstract: Proteins of the DUF866 superfamily are exclusively found in eukaryotic cells. A member of the DUF866 superfamily, C1ORF123, is a human protein found in the open reading frame 123 of chromosome 1. The physiological role of C1ORF123 is yet to be determined. The only available protein structure of the DUF866 family shares just 26% sequence similarity and does not contain a zinc binding motif. Here, we present the crystal structure of the recombinant human C1ORF123 protein (rC1ORF123). The structure has a 2-fold internal symmetry dividing the monomeric protein into two mirrored halves that comprise of distinct electrostatic potential. The N-terminal half of rC1ORF123 includes a zinc-binding domain interacting with a zinc ion near to a potential ligand binding cavity. Functional studies of human C1ORF123 and its homologue in the fission yeast (SpEss1) point to a role of DUF866 protein in mitochondrial oxidative phosphorylation.

PubMed: 30280012
DOI: 10.7717/peerj.5377

実験手法

X-RAY DIFFRACTION (1.9 Å)